The upsets continued in McDonald's Women's NSW Premier Cricket when two top four sides were dispatched in another unpredictable round of matches.

Penrith was last coming into western derby against second-placed Parramatta but turned recent form on its head to record an impressive 37-run win.

Universities have shown signs of improvement in recent weeks and took that up a cog, knocking over competition leader Sydney at Drummoyne Oval.

In the other matches, Northern District was a big winner over Gordon and St George-Sutherland defeated Campbelltown-Camden.

The return of WBBL players – combined with a lift in form from those outside the top four – have made it very difficult to predict results with any level of confidence.

Penrith coach Ron Woods was confident his Lady Cats would push Parramatta all the way and was delighted to come away with a major scalp.

Phoebe Litchfield's controlled 67 and handy contributions from Elsa Hunter (47) and Eloise Williams (34) helped Penrith reach 228.

A host of Parramatta batters made starts but none were able to go on it, the Lady Cats bowling the visitors out for 191.

Gabby Sutcliffe (3-38) and Elise Noble (2-31) led the way with the ball.

"We toughed it out after losing early wickets, " Woods said.

"Phoebe settled the batting with tremendous discipline and shot selection and Elsa and Eloise batted very well under pressure

"Parra are a good team led well by Hayley (Silver-Holmes) so it was great to get another win against a quality side.

"We are playing some good cricket in patches and hopefully we can keep it going."

Sydney had only lost one game before running headlong into a focused Universities side.

Skipper Maddy Darke anchored the innings with a composed 46 at the top of the order but wickets started to fall regularly until No.8 Erica James steadied things with 31 invaluable runs.

Defending 164, Universities' bowling attack ripped through the top and middle order to leave Sydney 5-34.

The competition front-runners staged a mini recovery before being bowled out for 133 in the 40th over.

Carly Leeson (5-19) and Jade Allen (4-33) were the chief destroyers.

St George-Sutherland is back on top of the table from Sydney, Parramatta and Northern District.

Full scores here