New South Wales lost by four wickets to Queensland in Brisbane on Sunday, but it was nevertheless a special day for two 26-year-old debutants during the Blues first match of the Marsh One-Day Cup.

Middle-order batsman Nick Bertus and Sydney Thunder paceman Nathan McAndrew both made their One-Day domestic debuts becoming the 186th and 187th to play limited-overs cricket for NSW.

Bertus impressed with 69 not out from 60 balls towards the back end of the Blues innings and contributed to a solid 5/305 which Queensland chased down in 48 overs. The hosts finished 6/307.

McAndrew (1-39) also claimed his maiden wicket removing danger man Sam Heazlett (70 from 57) leg before wicket.

Heazlett and Australian Test No. 3 Marnus Labuschagne (67 from 64 balls) set the tone early for Queensland, with some fast scoring, and were pivotal to the victory.

Earlier, Jack Edwards top scored for the match with 84 from 103 including nine fours and three sixes.

The 19-year-old and Moises Henriques (52 from 59) continued their knack of big partnerships against Queensland in One-Day cricket.

They posted 121 for the second wicket on Sunday following up their massive 237-run stand that guided the Blues to victory last season at Drummoyne Oval. 

Fast bowler Harry Conway picked up two wickets, including Labuschagne, and forced a run out to keep the Blues in the contest during the middle overs. In five overs, Queensland fell from 3/179 to 5/199 with 20 remaining.

Conway finished the match with 3-72 from 10 overs. Paceman Sean Abbott also bowled well, but without luck, taking 1-41 from his 10.

Seamer Mickey Edwards, brother of Jack, survived with bruising to his right hand after narrowly avoiding a potentially serious blow to the head as Heazlett crashed a shot straight back at the bowler.

He continued to bowl, delivering nine wicketless overs for 61.

The experienced Joe Burns (54 not out from 66) and allrounder Jack Wildermuth (51 from 56) ultimately guided the hosts home comfortably.

The Blues next play South Australia at the same venue on Thursday.

Scorecard here.