Daniel Hughes scored his fourth limited overs century for the NSW Blues but it wasn't enough to guide his side to victory in Monday’s Marsh One-Day Cup match at Drummoyne Oval.

Hughes made an unbeaten 112 from just 96 deliveries as the Blues lost to the Western Australia by eight runs in a rain affected match under the Duckworth Lewis Stern method.

It was the third straight loss the Blues have suffered in the competition. Their next match is on Wednesday, also against Western Australia at Drummoyne Oval.

The Blues reached 7/235 chasing a revised target of 244 to win.

Leg-spinner Daniel Fallins, 23, and dynamic top order batsman Matt Gilkes, 20, both made their One-Day debuts for NSW on Monday.

Hughes and Moises Henriques (75 from 65) put the Blues in a strong position at 1/154 in the 24th over with the match reduced to 35 overs per side due to the rain.

The pair shared a 142-run partnership for the second wicket, from just under 20 overs, before Henriques was dismissed and momentum slowed.

Hughes reached the boundary 12 times during his century and cleared it once. Henriques hit four powerful sixes and six fours.

Earlier, Blues Captain Peter Nevill won the toss and elected to send the Western Australians in to bat, under a cloudy sky.

Henriques picked up 2-41 from five overs of his medium pace. Off-spinner Arjun Nair also claimed 2-18 from three, with former Test batsman Shaun Marsh top-scoring for WA, making 82 from 84 balls.

When Henriques departed in the 24th over off the bowling of Nathan Coulter-Nile (3-47) victory still seemed likely for the Blues. Debutant Matthew Gilkes joined Hughes at the crease, and during a quick 39-run partnership, Hughes brought up his century.

Gilkes departed for 10, with the Blues still needing 51 from 35 balls. Daniel Sams contributed 14, including a six, before falling leg before wicket to Coulter-Nile, leaving the Blues at 4/214, still needing a further 30 from 18.

Nick Bertus contributed a six of his own before Coulter-Nile grabbed another wicket, Bertus departing for seven.

Skipper Nevill joined Hughes and needing to pull off a captain’s knock with his side needing 20 off the last 10. Unfortunately, he was unable to do so, falling for a single run on the first ball of the final over.

The Blues losing 3/11 in the final two overs to fall eight runs short.

Scorecard here